By: Xie, Bingyu; Guo, Jianwei; Liu, Sa; Peng, Jinping
Youji Huaxue (2011), 31(4), 486-489 | Language: Chinese, Database: CAplus
3-Amino-1-adamantanol, a key intermediate of anti-diabetic drug, was successfully synthesized via bromination, azido, Curtius
rearrangement and hydrolysis processes by using adamantane carboxylic acid as the starting raw material. The overall yield of 3-
amino-1-adamantanol was 34%. 3-Amino-1-adamantane carboxylic acid hydrochloride, a anti-neoplastic agents, was synthesized
from adamantane carboxylic acid by Ritter, hydrolysis reaction in total yield of 73%. The structures of products were identified by
elemental anal., IR, MS, H NMR, etc.