IUPAC Name
N-(2,3-bis(oleoyloxy)propyl)-N,N-dimethylprop-2-yn-1-aminium bromide
Chemical Formula
C₄₆H₈₈BrNO₄
Molecular Weight
814
Form
Solid
SMILES
O=C(OCC(C[N+](C)(CC#C)C)OC(CCCCCCC/C=C\CCCCCCCC)=O)CCCCCCC/C=C\CCCCCCCC.[Br-]
Synonyms
DOCPAB; Propargyl-DOTAP analogue
N-(2,3-bis(oleoyloxy)propyl)-N,N-dimethylprop-2-yn-1-aminium bromide is a cationic, unsaturated lipid derived from DOTAP but with a propargyl (alkyne) substituent on its headgroup. It forms positively charged, fluid bilayers suitable for gene delivery and bioconjugation via click chemistry. Its structural design balances membrane fluidity, electrostatic binding to nucleic acids, and chemical reactivity for advanced liposome modification.
