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En route to clinic, chemical matter has to be thoroughly prosecuted such that few surprises, if any, appear during IND enabling GLP studies. This process involves sound judgement, thoughtful risk assessment and continued iteration of the lead and back-up compounds to achieve desired drug-like characteristics. Much consideration has to be given to:
AAPharmaSyn partners with researchers within private and public sector to accelerate their programs toward clinical development. We accomplish this through:
1. Work-in-kind and financial investment via SAFE (simple agreement for future equity) or similar instruments.
2. SBIR/STTR grants and other public and private grants
3. Private placements
Academia
RO1, R03, R021 / STTR / Other Grant
Academic Investigator
Biological Target
Funding
Gap
Lead Optimization
Screening
IND enabling studies
The penultimate objective of AAPharmaSyn Research Collaboration is to bridge translational research funding gap. We believe that many breakthrough therapies never reach the clinic for reasons that have little to do with fundamental science and a lot to do with misallocation of scarce resources.
Resources
Time
Academia
